Fig. 2

Everolimus trial Prior medians A, posterior medians daily B, and sequential C, 50% equi-tailed credible intervals (thick lines), and 95% equi-tailed credible intervals (thin lines) of daily doses for DLT probabilities obtained by BLRM (BLRM-MAP for Sequential), CRM (B-CRM for Sequential), and for end-of-cycle 1 DLT probabilities obtained by TITE-PK. Prior skeletons are shown for CRM in the plot A. “Sequential” refers that analysis is done by assuming the trial is conducted sequentially, namely firstly weekly schedule, secondly daily schedule. Also, “Daily” means data only from daily schedule is considered. Vertical dashed lines (0.20-0.40) are the boundaries of the targeted toxicity interval