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Table 2 Scenarios 1-6 in the simulation study. Doses with dose limiting toxicities in the targeted toxicity interval (0.20 - 0.40) are in boldface. Scenarios 1-6 represent phase I trials with one schedule, that is daily schedule

From: Phase I dose-escalation oncology trials with sequential multiple schedules

 

Doses in mg

Scenario

2.5

5

7.5

10

12.5

15

1

0.05

0.10

0.20

0.30

0.50

0.70

2

0.30

0.40

0.52

0.61

0.76

0.87

3

0.05

0.06

0.08

0.11

0.19

0.34

4

0.06

0.08

0.12

0.18

0.40

0.71

5

0.10

0.22

0.31

0.45

0.60

0.72

6

0.50

0.55

0.61

0.69

0.76

0.87