Table 5 Simulation results for TITE-PK, B-CRM, and BLRM-MAP in Scenarios 7-13

Probability of selecting MTD in the targeted toxicity interval

TITE-PK

0.90

0.70

0.94

0.84

0.62

n/a

0.17

B-CRM

0.83

0.50

0.64

0.60

0.52

n/a

0.77

BLRM MAP

0.95

0.56

0.77

0.68

0.46

n/a

0.55

Probability of selecting MTD in the overdosing interval

TITE-PK

n/a

0.22

0.05

0.02

0.37

0.02

n/a

B-CRM

n/a

0.38

0.08

0.00

0.28

0.25

n/a

BLRM MAP

n/a

0.40

0.21

0.10

0.41

0.03

n/a

Probability of selecting no combination as MTD

TITE-PK

0.00

0.02

0.01

0.14

0.00

0.98

0.15

B-CRM

0.00

0.02

0.02

0.28

0.20

0.75

0.00

BLRM MAP

0.00

0.02

0.02

0.22

0.12

0.97

0.01

Mean number of patients enrolled

TITE-PK

21.7

21.7

21.4

19.4

21.8

3.7

19.7

B-CRM

21.0

21.0

21.0

18.0

19.0

9.0

21.1

BLRM MAP

21.5

23.6

21.6

20.0

22.8

4.8

23.4

Proportion of patients enrolled in the overdosing interval

TITE-PK

n/a

0.39

0.17

0.12

0.61

1.00

n/a

B-CRM

n/a

0.46

0.15

0.06

0.72

1.00

n/a

BLRM MAP

n/a

0.59

0.40

0.26

0.70

1.00

n/a

Mean number of DLT observed

TITE-PK

5.3

8.2

6.2

7.5

10.2

1.8

2.4

B-CRM

4.5

7.0

7.3

7.5

8.5

4.0

3.0

BLRM MAP

5.7

9.7

7.7

8.2

11.1

2.4

3.9