Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

Table 1 Primary Analysis: MCIDs for Two Measures of Cognitive Function

	# RCTs (# Participants)	SD Range	Pooled SD	MCID: 0.4 x SD	MCID: 0.5 x SD
MMSE
Baseline SDs	51 (12449)	0.94 to 6.80	4.0	1.6	2.0
Mean Change SDs	36 (10575)	0.33 to 6.12	3.6	1.4	1.8
ADAS-Cog
Baseline SDs	37 (10006)	2.55 to 17.30	10.0	4.0	5.0
Mean Change SDs	38 (13288)	1.32 to 12.85	6.4	2.6	3.2

Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)

ISSN: 1471-2288