Skip to main content

Table 1 Primary Analysis: MCIDs for Two Measures of Cognitive Function

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

  # RCTs
(# Participants)
SD Range Pooled SD MCID:
0.4 x SD
MCID:
0.5 x SD
MMSE
 Baseline SDs 51 (12449) 0.94 to 6.80 4.0 1.6 2.0
 Mean Change SDs 36 (10575) 0.33 to 6.12 3.6 1.4 1.8
ADAS-Cog
 Baseline SDs 37 (10006) 2.55 to 17.30 10.0 4.0 5.0
 Mean Change SDs 38 (13288) 1.32 to 12.85 6.4 2.6 3.2
  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)