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Table 2 Sensitivity Analysis: MCIDs for Two Measures of Cognitive Function

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

 

# RCTs

(# Participants)

SD Range

Pooled SD

MCID:

0.4 x SD

MCID:

0.5 x SD

MMSE

 Baseline SDs

38 (9614)

1.30 to 6.80

4.0

1.6

2.0

 Mean Change SDs

12 (5288)

0.33 to 4.34

3.5

1.4

1.8

ADAS-Cog

 Baseline SDs

26 (5744)

4.60 to 17.3

9.9

4.0

5.0

 Mean Change SDs

8 (3320)

1.32 to 7.88

6.4

2.6

3.2

  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)
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BMC Medical Research Methodology

ISSN: 1471-2288

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