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Table 2 Sensitivity Analysis: MCIDs for Two Measures of Cognitive Function

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

  # RCTs
(# Participants)
SD Range Pooled SD MCID:
0.4 x SD
MCID:
0.5 x SD
MMSE
 Baseline SDs 38 (9614) 1.30 to 6.80 4.0 1.6 2.0
 Mean Change SDs 12 (5288) 0.33 to 4.34 3.5 1.4 1.8
ADAS-Cog
 Baseline SDs 26 (5744) 4.60 to 17.3 9.9 4.0 5.0
 Mean Change SDs 8 (3320) 1.32 to 7.88 6.4 2.6 3.2
  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)