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Table 3 Secondary Analysis by Intervention Group: MCIDs for Two Measures of Cognitive Function

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

  # RCTs
(# Participants)
SD Range Pooled SD MCID:
0.4 x SD
MCID:
0.5 x SD
Donepezil
MMSE
  Baseline SDs 35 (3785) 1.08 to 5.90 4.2 1.7 2.1
  Mean Change SDs 28 (3125) 0.33 to 6.12 3.6 1.4 1.8
ADAS-Cog
  Baseline SDs 22 (1693) 6.56 to 15.8 10.2 4.1 5.1
  Mean Change SDs 20 (2215) 3.96 to 7.46 5.8 2.3 2.9
Galantamine
MMSE
  Baseline SDs 7 (1285) 1.92 to 4.12 3.9 1.6 2.0
  Mean Change SDs 5 (1102) 2.24 to 4.05 3.9 1.6 2.0
ADAS-Cog
  Baseline SDs 16 (2296) 5.02 to 11.78 9.7 3.9 4.9
  Mean Change SDs 22 (3179) 5.00 to 7.43 6.0 2.4 3.0
Rivastigmine
MMSE
  Baseline SDs 17 (1944) 0.98 to 4.9 3.5 1.4 1.8
  Mean Change SDs 12 (1891) 0.46 to 3.6 3.2 1.3 1.6
ADAS-Cog
  Baseline SDs 14 (1825) 4.60 to 12.30 10.0 4.0 5.0
  Mean Change SDs 15 (2892) 1.32 to 12.85 7.1 2.8 3.6
Memantine
MMSE
  Baseline SDs 9 (548) 1.60 to 6.20 4.0 1.6 2.0
  Mean Change SDs 4 (442) 2.20 to 5.65 4.1 1.6 2.1
ADAS-Cog
  Baseline SDs 5 (706) 7.90 to 11.01 10.0 4.0 5.0
  Mean Change SDs 3 (603) 5.46 to 9.77 8.2 3.3 4.1
Placebo
MMSE
  Baseline SDs 36 (4396) 0.94 to 6.8 4.1 1.6 2.1
  Mean Change SDs 27 (3758) 0.33 to 5.76 3.7 1.5 1.9
ADAS-Cog
  Baseline SDs 28 (3398) 2.55 to 17.3 10.1 4.1 5.1
  Mean Change SDs 29 (4315) 2.50 to 8.19 6.3 2.5 3.2
  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)