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Table 4 Comparison of Derived to Published MCIDs

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

 

Published MCIDs

Derived MCID: 0.4 x SD

Derived MCID: 0.5 x SD

MMSE

 Baseline SDs

1.7 to 2.1 [6]

1.6

2.0

 Mean Change SDs

1 to 2 [6]; 1.4 to 1.7 [6]; 3.72 [12]

1.4

1.8

ADAS-Cog

 Baseline SDs

3.3 to 4.9 [22]

4.0

5.0

 Mean Change SDs

2.7 to 3.8 [22]; 4 [20]

2.6

3.2

  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), standard deviation (SD)
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BMC Medical Research Methodology

ISSN: 1471-2288

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