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Table 4 Comparison of Derived to Published MCIDs

From: Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

  Published MCIDs Derived MCID: 0.4 x SD Derived MCID: 0.5 x SD
MMSE
 Baseline SDs 1.7 to 2.1 [6] 1.6 2.0
 Mean Change SDs 1 to 2 [6]; 1.4 to 1.7 [6]; 3.72 [12] 1.4 1.8
ADAS-Cog
 Baseline SDs 3.3 to 4.9 [22] 4.0 5.0
 Mean Change SDs 2.7 to 3.8 [22]; 4 [20] 2.6 3.2
  1. Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), standard deviation (SD)