The Lancet (n = 51) |
NEJM (n = 67) |
Total (n = 118) | ||||
---|---|---|---|---|---|---|
Type of Intervention | ||||||
Behaviour (diet, exercise, cognitive) | 5 | 10% | 4 | 6% | 9 | 8% |
Medical device | 6 | 12% | 1 | 1% | 7 | 6% |
Diagnostic | 2 | 4% | 0 | 0% | 2 | 2% |
Drug | 19 | 37% | 47 | 70% | 66 | 56% |
Health service strategies | 5 | 10% | 2 | 3% | 7 | 6% |
Psychological | 5 | 10% | 0 | 0% | 5 | 4% |
Surgical | 9 | 18% | 13 | 19% | 22 | 19% |
Number of Participants | ||||||
< 100 | 2 | 4% | 4 | 6% | 6 | 5% |
100 to 499 | 24 | 47% | 20 | 30% | 44 | 37% |
500 to 999 | 16 | 31% | 21 | 31% | 37 | 31% |
1000 to 4999 | 8 | 16% | 14 | 21% | 22 | 19% |
≥ 5000 | 1 | 2% | 8 | 12% | 9 | 8% |
Proportion of Missing Primary Outcome Data | ||||||
< 10% | 21 | 41% | 33 | 49% | 54 | 46% |
10 to 19% | 17 | 33% | 23 | 34% | 40 | 34% |
20 to 29% | 6 | 12% | 4 | 6% | 10 | 8% |
≥ 30% | 3 | 6% | 4 | 6% | 7 | 6% |
not clear | 4 | 8% | 3 | 4% | 7 | 6% |
Type of Primary Outcome | ||||||
Binary | 20 | 39% | 34 | 51% | 54 | 46% |
Continuous | 27 | 53% | 30 | 45% | 57 | 48% |
Count | 4 | 8% | 0 | 0% | 4 | 3% |
Time-to-event | 0 | 0% | 3 | 4% | 3 | 3% |
Assessed Differences Between Participants with Complete and Incomplete Data | ||||||
Yes | 5 | 10% | 6 | 9% | 11 | 9% |
No | 46 | 90% | 61 | 91% | 107 | 91% |
Method of Handling Missing Data in Primary Analysis | ||||||
MAR MIa | 22 | 44% | 21 | 31% | 43 | 36% |
Controlled MI | 1 | 2% | 1 | 1% | 2 | 2% |
Complete case | 19 | 38% | 39 | 57% | 58 | 49% |
Single imputation | 5 | 10% | 5 | 7% | 10 | 8% |
Last observation carried forward | 3 | 6% | 2 | 3% | 5 | 4% |
Conducted Missing Data Sensitivity Analysis | ||||||
Yes | 36 | 71% | 59 | 88% | 95 | 81% |
No | 15 | 29% | 8 | 12% | 23 | 19% |
Method of Handling Missing Data in Sensitivity Analysis Where Sensitivity Was Conductedb | ||||||
MAR MI | 28 | 68% | 42 | 54% | 70 | 59% |
Controlled MI | 3 | 7% | 11 | 14% | 14 | 12% |
Complete case | 6 | 15% | 10 | 13% | 16 | 13% |
Single imputation | 1 | 2% | 8 | 10% | 9 | 8% |
Last observation carried forward | 1 | 2% | 6 | 8% | 7 | 6% |
Others | 2 | 5% | 1 | 1% | 3 | 3% |
Method of Controlled MI (primary or sensitivity analysis) | ||||||
Reference-based | 2 | 40% | 5 | 45% | 7 | 44% |
Delta-based | 3 | 60% | 6 | 55% | 9 | 56% |