Level of Concordance | Rare Disease | Non-rare Disease | Symptom-specific |
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SF-36 (n = 11) | EQ-5D (n = 0) | SF-36 (n = 84) | EQ-5D (n = 65) | SF-36 (n = 66) | EQ-5D (n = 31) |
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None | 2 (18%) | – | 25 (30%) | 23 (35%) | 24 (36%) | 5 (16%) |
Moderate | 6 (55%) | – | 35 (42%) | 25 (38%) | 30 (45%) | 17 (55%) |
Strong | 3 (27%) | – | 24 (29%) | 17 (26%) | 12 (18%) | 9 (29%) |
- Values represent number of studies (% of total). Rare disease: affecting < 1 in 2000 population; Non-rare diseases: ≥1 in 2000 population. Concordance: None (No) = significant impact on quality of life with disease/condition specific tool, but no change or the opposite impact with generic tool (or vice versa); Moderate = quality of life impact was scored in the same direction with both tools, but statistically significant with only one of them; Strong = results fully aligned (significant/non-significant impact in same direction)