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Table 1 Summary characteristics of the five scenarios considered to emulate the ZODIAC trial

From: Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

  β1 β2 ρ gAHR(24) Events \({p_{*}^{(a)}}\) N Emp. Power
Scenario 1 1 1 0.1 0.808 1,106 0.952 1,162 0.894
Scenario 2 1 1 0.5 0.816 1,208 0.900 1,344 0.898
Scenario 3 1 2 0.5 0.803 1,044 0.981 1,066 0.896
Scenario 4 1 0.5 0.5 0.823 1,313 0.842 1,560 0.895
Scenario 5 2 0.5 0.5 0.825 1,349 0.814 1,658 0.902
  1. gAHR(24): geometric Average Hazard Ratio at 24 months; \(\boldsymbol {p}_{\mathbf {*} }^{\boldsymbol {(a)}}\): Probability of observing composite event in either group; N: Sample size (both groups combined) rounded to an even number