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Table 1 Summary characteristics of the five scenarios considered to emulate the ZODIAC trial

From: Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

 

β1

β2

ρ

gAHR(24)

Events

\({p_{*}^{(a)}}\)

N

Emp. Power

Scenario 1

1

1

0.1

0.808

1,106

0.952

1,162

0.894

Scenario 2

1

1

0.5

0.816

1,208

0.900

1,344

0.898

Scenario 3

1

2

0.5

0.803

1,044

0.981

1,066

0.896

Scenario 4

1

0.5

0.5

0.823

1,313

0.842

1,560

0.895

Scenario 5

2

0.5

0.5

0.825

1,349

0.814

1,658

0.902

  1. gAHR(24): geometric Average Hazard Ratio at 24 months; \(\boldsymbol {p}_{\mathbf {*} }^{\boldsymbol {(a)}}\): Probability of observing composite event in either group; N: Sample size (both groups combined) rounded to an even number
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BMC Medical Research Methodology

ISSN: 1471-2288

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