Skip to main content

Table 3 Proportion of group-sequential trials with subjects numbers superior to fixed designs NSN (pC = 0.50)

From: Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak

  ∆ = 0.2 ∆ = 0.1 ∆ = 0 ∆ = − 0.1
Standard S1 0.07 0.13 0.02 0.0004
S2 0.09 0.15 0.02 0.0003
Changing
with time
S1 0.02 0.13 0.04 0.001
S2 0.1 0.23 0.03 0.0005
  1. Abbreviations: pC indicates control survival rate; ∆: simulated survival rate difference; F1: fixed single-arm design; S1: group-sequential single-arm design; F2: fixed two-arm design; S2: group-sequential two-arm design; “Standard”: specific case with a fixed control survival rate; “Changing with time”: specific case with an increase of the control survival rate over time