| ∆ = 0.2 | ∆ = 0.1 | ∆ = 0 | ∆ = − 0.1 |
---|
Standard | S1 | 0.07 | 0.13 | 0.02 | 0.0004 |
S2 | 0.09 | 0.15 | 0.02 | 0.0003 |
Changing with time | S1 | 0.02 | 0.13 | 0.04 | 0.001 |
S2 | 0.1 | 0.23 | 0.03 | 0.0005 |
- Abbreviations: pC indicates control survival rate; ∆: simulated survival rate difference; F1: fixed single-arm design; S1: group-sequential single-arm design; F2: fixed two-arm design; S2: group-sequential two-arm design; “Standard”: specific case with a fixed control survival rate; “Changing with time”: specific case with an increase of the control survival rate over time