Fig. 1

Hypothesized multivariable CRF model in CCS. Model showing associated factors of CRF divided into predisposing- (genetic factors and blood biomarkers which are thought to impact the vulnerability to fatigue), triggering- (factors related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms), maintaining- (daily life- and psychosocial factors which may perpetuate fatigue once triggered) and moderating factors (factors which might influence the way fatigue symptoms express in individuals). Continuous lines: factors that are hypothesized to be directly related to CRF. Dashed lines: factors that are hypothesized to possibly act as moderator or confounder for other factors, but might also directly be related to CRF. BMI: Body Mass Index. * Included comorbidities are categorized into the following main organ systems: Neoplasms, Cardiac-, vascular-, respiratory-, gastro-intestinal-, hepatobiliary-, renal and urinary tract-, endocrine-, musculoskeletal-, ear-, eye-, nervous system-, and other conditions