Skip to main content

Table 3 Estimated association between NSAID use and severe upper gastrointestinal bleeding

From: A new likelihood model for analyses of pharmacoepidemiologic case–control studies which avoids decision rules for determining latent exposure status

Exposure definition n Crude OR (95% confidence interval) Adjusted OR (95% confidence interval) Upper/lower confidence limit ratio for adjusted OR
Fixed window, 30 days 9,453    
Conditional   7.06 (6.17—8.06) 5.17 (2.40—11.11) 4.62
Ordinary   6.91 (6.19—7.71) 3.85 (2.09—7.07) 3.38
Fixed window, 90 days 12,662    
Conditional   4.96 (4.46—5.51) 4.73 (2.72—8.23) 3.02
Ordinary   4.87 (4.43—5.36) 3.52 (2.19—5.65) 2.58
WTD treatment probability 39,119    
Conditional   6.99 (6.35—7.69) 4.37 (3.62—5.28) 1.46
Ordinary   6.90 (6.28—7.58) 3.94 (3.29—4.72) 1.43
Joint likelihood model 39,119 5.57 (5.08 ‐ 6.05) 2.52 (1.59 – 3.45) 2.18
  1. Case–control study of 3568 cases and 35,552 controls. See text for technical description of exposure definitions and covariate adjustment. Conditional results are based on conditional logistic regression which accounts for matching on age and sex. Ordinary results are based on ordinary logistic regression (unconditional), but where sex and age are included as covariates, both in the crude and adjusted analyses