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Table 2 Details of second outcomes for meta-analyses

From: Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Meta_analysis

Reference

Study

Second_outcome

Third_outcome

Year

Second outcome RCT no.

Second outcome total patients

Second outcome total events

I^2

Second outcome sse graphics

Second outcome sse test

Griesdale

[34]

Bivariate

Hypoglcaemia

 

2009

14

12,337

752

38.15

query

0.340

Annane

[35]

Bivariate

Shock reversal

 

2009

7

1368

708

67.95

query

0.230

Bangalore

[36]

Trivariate

Non-fatal MI

Non-fatal stroke

2008

20

11,734

436

0.00

query

0.052

Marik

[37]

Trivariate

Infection

Hospital LOS

2008

9

1828

725

35.34

query

0.008

Marik

[37]

Trivariate

Hospital LOS

Infection

2008

4

147

N/A

60.69

ok

0.370

Marik

[37]

Trivariate

Hospital LOS

Infection

2008

5

227

N/A

87.00

ok

0.150

Chan

[38]

Trivariate

VAP

MV length

2007

7

300

120

57.44

query

0.130

Gonzalez

[39]

Bivariate

Rebleeding

 

2008

18

1304

409

46.29

ok

0.670

Ho

[40]

Trivariate

Pneumonia

ICULOS

2006

4

216

42

1.88

ok

0.800

Ho

[41]

Bivariate

ICU LOS

 

2008

7

454

N/A

76.86

ok

0.550

Siempos

[42]

Bivariate

VAP

 

2010

10

1958

310

0.00

ok

0.470

Singh

[43]

Bivariate

Pneumonia

 

2009

11

7514

465

36.50

ok

0.250

Peterson

[44]

Bivariate

Neurological outcome

 

2008

8

781

357

57.37

query

0.540

Silvestri

[45]

Bivariate

infection

 

2007

31

4747

625

26.61

ok

0.550

Whitlock

[46]

Trivariate

New Atrial fibrillation

Bleed post-operative

2008

8

1090

332

0.00

ok

0.240

Piccini

[47]

Trivariate

CVS death

Cardiomyopathy

2009

14

8244

1252

1.27

ok

0.050

Landoni

[48]

Bivariate

MI

 

2010

14

849

17

0.00

ok

0.576

Brar

[49]

Trivariate

MI

TVR

2009

13

7352

261

0.00

ok

0.471

Landoni

[50]

Trivariate

Acute kidney injury

Hospital LOS

2007

9

1037

242

0.00

query

0.917

Mazaki

[51]

Bivariate

Infection

 

2008

8

1250

252

16.87

ok

0.497

Masip

[52]

Bivariate

Intubation

 

2005

9

468

192

0.00

ok

0.728

Oldani

[53]

Trivariate

Infection

Hospital LOS

2015

12

1941

1158

75.88

query

0.006

Szakmany

[54]

Trivariate

VAP

MV length

2015

6

1048

389

54.60

query

0.114

Alkhawaja

[55]

Trivariate

Pneumonia

ICU LOS

2015

8

801

189

8.41

ok

0.778

Van Zanten

[56]

Trivariate

Infection

Hospital LOS

2015

4

776

296

0.00

ok

0.085

Wan

[57]

Bivariate

Hospital LOS

MV length

2015

4

217

N/A

99.47

query

0.354

Teo

[58]

Bivariate

Clinical response

 

2014

4

814

639

0.00

ok

0.278

Manzanares

[59]

Trivariate

Infection

MV length

2012

10

1742

449

0.00

ok

0.663

Tian

[60]

Trivariate

Pneumonia

Hospital LOS

2018

9

2994

354

37.90

query

0.001

Rhodes

[61]

Bivariate

Cinical cure

 

2018

10

1935

1315

47.80

query

0.016

Nunez-Patino

[62]

Trivariate

Neurological outcome

ICU LOS

2018

5

981

598

59.04

ok

0.080

Kawano-Dourado

[63]

Bivariate

RRT

 

2018

7

3463

125

0.00

ok

0.483

Dallimore

[64]

Bivariate

ICU LOS

 

2018

6

1069

N/A

0.00

ok

0.249

Chong

[65]

Bivariate

Myocardial infarction

 

2018

13

7269

136

17.31

ok

0.427

Yang

[66]

Trivariate

Renal function recovery

RRT time

2017

6

1292

43

0.00

ok

0.625

Osadnik

[67]

Trivariate

Hospital LOS

MV

2017

9

869

N/A

9.70

ok

0.442

Lu

[68]

Trivariate

ICU LOS

MV length

2017

11

865

N/A

86.68

ok

0.439

Chen

[69]

Trivariate

ICU LOS

RRT

2017

10

1746

N/A

91.38

ok

0.726

Qureshi

[70]

Bivariate

Acute kidney injury

 

2016

7

8203

1012

0.00

query

0.206

Elke

[71]

Trivariate

Infection

Hospital LOS

2016

9

2768

521

47.95

query

0.060

Parikh

[72]

Trivariate

Hospital LOS

ICU LOS

2016

7

830

N/A

86.83

query

0.751

Davies

[73]

Trivariate

VAP

Hospital LOS

2017

6

2064

1720

53.03

query

0.536

Abroug

[74]

Bivariate

Clinical response

 

2014

9

1097

764

0.00

query

0.383

Manzanares

[75]

Bivariate

infection

 

2016

8

761

292

42.79

query

0.031

Peter

[76]

Trivariate

Mechanical ventilation

Hospital LOS

2002

12

695

214

16.56

ok

0.948

Wang

[77]

Trivariate

Rebleeding

Surgery

2010

6

1052

86

0.00

ok

0.747

Tao

[78]

Trivariate

Infection

MV length

2016

5

457

118

0.00

ok

0.143

Tang

[79]

Trivariate

Antibiotic exposure

ICU LOS

2009

6

1386

N/A

97.11

ok

0.828

Muscedere

[80]

Trivariate

VAP

MV length

2011

6

1682

212

0.00

ok

0.266

  1. LOS Length of stay (days), ICU Intensive care unit, VAP Ventilator associated pneumonia, CVS Cardiovascular, MV Mechanical ventilation, TVR Target vessel revascularization, RRT Renal replacement therapy, MI Myocardial infarction, Ok Visual assessment of contour-enhanced revealed no problematic asymmetry, query Visual assessment of contour-enhanced revealed problematic asymmetry