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Table 2 Details of second outcomes for meta-analyses

From: Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Meta_analysis Reference Study Second_outcome Third_outcome Year Second outcome RCT no. Second outcome total patients Second outcome total events I^2 Second outcome sse graphics Second outcome sse test
Griesdale [34] Bivariate Hypoglcaemia   2009 14 12,337 752 38.15 query 0.340
Annane [35] Bivariate Shock reversal   2009 7 1368 708 67.95 query 0.230
Bangalore [36] Trivariate Non-fatal MI Non-fatal stroke 2008 20 11,734 436 0.00 query 0.052
Marik [37] Trivariate Infection Hospital LOS 2008 9 1828 725 35.34 query 0.008
Marik [37] Trivariate Hospital LOS Infection 2008 4 147 N/A 60.69 ok 0.370
Marik [37] Trivariate Hospital LOS Infection 2008 5 227 N/A 87.00 ok 0.150
Chan [38] Trivariate VAP MV length 2007 7 300 120 57.44 query 0.130
Gonzalez [39] Bivariate Rebleeding   2008 18 1304 409 46.29 ok 0.670
Ho [40] Trivariate Pneumonia ICULOS 2006 4 216 42 1.88 ok 0.800
Ho [41] Bivariate ICU LOS   2008 7 454 N/A 76.86 ok 0.550
Siempos [42] Bivariate VAP   2010 10 1958 310 0.00 ok 0.470
Singh [43] Bivariate Pneumonia   2009 11 7514 465 36.50 ok 0.250
Peterson [44] Bivariate Neurological outcome   2008 8 781 357 57.37 query 0.540
Silvestri [45] Bivariate infection   2007 31 4747 625 26.61 ok 0.550
Whitlock [46] Trivariate New Atrial fibrillation Bleed post-operative 2008 8 1090 332 0.00 ok 0.240
Piccini [47] Trivariate CVS death Cardiomyopathy 2009 14 8244 1252 1.27 ok 0.050
Landoni [48] Bivariate MI   2010 14 849 17 0.00 ok 0.576
Brar [49] Trivariate MI TVR 2009 13 7352 261 0.00 ok 0.471
Landoni [50] Trivariate Acute kidney injury Hospital LOS 2007 9 1037 242 0.00 query 0.917
Mazaki [51] Bivariate Infection   2008 8 1250 252 16.87 ok 0.497
Masip [52] Bivariate Intubation   2005 9 468 192 0.00 ok 0.728
Oldani [53] Trivariate Infection Hospital LOS 2015 12 1941 1158 75.88 query 0.006
Szakmany [54] Trivariate VAP MV length 2015 6 1048 389 54.60 query 0.114
Alkhawaja [55] Trivariate Pneumonia ICU LOS 2015 8 801 189 8.41 ok 0.778
Van Zanten [56] Trivariate Infection Hospital LOS 2015 4 776 296 0.00 ok 0.085
Wan [57] Bivariate Hospital LOS MV length 2015 4 217 N/A 99.47 query 0.354
Teo [58] Bivariate Clinical response   2014 4 814 639 0.00 ok 0.278
Manzanares [59] Trivariate Infection MV length 2012 10 1742 449 0.00 ok 0.663
Tian [60] Trivariate Pneumonia Hospital LOS 2018 9 2994 354 37.90 query 0.001
Rhodes [61] Bivariate Cinical cure   2018 10 1935 1315 47.80 query 0.016
Nunez-Patino [62] Trivariate Neurological outcome ICU LOS 2018 5 981 598 59.04 ok 0.080
Kawano-Dourado [63] Bivariate RRT   2018 7 3463 125 0.00 ok 0.483
Dallimore [64] Bivariate ICU LOS   2018 6 1069 N/A 0.00 ok 0.249
Chong [65] Bivariate Myocardial infarction   2018 13 7269 136 17.31 ok 0.427
Yang [66] Trivariate Renal function recovery RRT time 2017 6 1292 43 0.00 ok 0.625
Osadnik [67] Trivariate Hospital LOS MV 2017 9 869 N/A 9.70 ok 0.442
Lu [68] Trivariate ICU LOS MV length 2017 11 865 N/A 86.68 ok 0.439
Chen [69] Trivariate ICU LOS RRT 2017 10 1746 N/A 91.38 ok 0.726
Qureshi [70] Bivariate Acute kidney injury   2016 7 8203 1012 0.00 query 0.206
Elke [71] Trivariate Infection Hospital LOS 2016 9 2768 521 47.95 query 0.060
Parikh [72] Trivariate Hospital LOS ICU LOS 2016 7 830 N/A 86.83 query 0.751
Davies [73] Trivariate VAP Hospital LOS 2017 6 2064 1720 53.03 query 0.536
Abroug [74] Bivariate Clinical response   2014 9 1097 764 0.00 query 0.383
Manzanares [75] Bivariate infection   2016 8 761 292 42.79 query 0.031
Peter [76] Trivariate Mechanical ventilation Hospital LOS 2002 12 695 214 16.56 ok 0.948
Wang [77] Trivariate Rebleeding Surgery 2010 6 1052 86 0.00 ok 0.747
Tao [78] Trivariate Infection MV length 2016 5 457 118 0.00 ok 0.143
Tang [79] Trivariate Antibiotic exposure ICU LOS 2009 6 1386 N/A 97.11 ok 0.828
Muscedere [80] Trivariate VAP MV length 2011 6 1682 212 0.00 ok 0.266
  1. LOS Length of stay (days), ICU Intensive care unit, VAP Ventilator associated pneumonia, CVS Cardiovascular, MV Mechanical ventilation, TVR Target vessel revascularization, RRT Renal replacement therapy, MI Myocardial infarction, Ok Visual assessment of contour-enhanced revealed no problematic asymmetry, query Visual assessment of contour-enhanced revealed problematic asymmetry