Skip to main content

Table 2 Optimization using NPML approach

From: Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

K

loglik

λopt

AICbm

1.00

-1593.02

0.35

3192.04

2.00

-1402.21

0.35

2814.41

3.00

-1310.29

0.45

2634.57

4.00

-1230.15

0.40

2478.30

5.00

-1164.85

0.40

2351.70

6.00

-1142.70

0.35

2311.39

7.00

-1127.57

0.35

2285.14

8.00

-1107.63

0.45

2249.26

9.00

-1102.10

0.45

2242.19

10.00

-1096.30

0.45

2234.60

  1. The table presents the optimal values of the transformation parameter λ that were obtained from fitting Model (2) with the boxcoxmix package [21] using the analysis data set. In addition, the respective log-likelihood and AICbm values (evaluated at the optimal λ values) are shown for varying numbers of mass points K. Following [21], the information criterion was defined as AICbm=−2 log(L)+2·(p+2K). Hence the AIC values in the fourth column cannot be directly compared to the AIC values presented in Fig. 2