An improved method for the effect estimation of the intermediate event on the outcome based on the susceptible pre-identification

Table 2 Details of the methods investigated in the simulation study

Method Code	The susceptible pre-identification		Effect estimation method		Analysis set
Method Code	LRM	RITI	exCox	LM	Entire population	Identified susceptible subpopulation	Real susceptible subpopulation
exCox1			✓		✓
exCox2	✓		✓			✓
exCox3		✓	✓			✓
exCox4			✓				✓
LM1				✓	✓
LM2	✓			✓		✓
LM3		✓		✓		✓
LM4				✓			✓

The proposed new methods were coded as exCox3 and LM3. Existing methods were coded as exCox1-exCox2 and LM1-LM2. The results of methods exCox4 and LM4 were served as the performance benchmark. Abbreviations: exCox extended Cox regression; LM landmark method; LRM logistic regression model; RITI residual intermediate-event time imputation

ISSN: 1471-2288