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Fig. 5 | BMC Medical Research Methodology

Fig. 5

From: Time-varying associations between an exposure history and a subsequent health outcome: a landmark approach to identify critical windows

Fig. 5

Mean change of the TICS score over the study course following 5 theoretical BMI history profiles defined all over the whole 24 years preceding the first cognitive interview: (i) linear decrease of 5 points of BMI (purple lines), (ii) linear decrease of 10 points of BMI (blue lines), (iii) stable BMI (dashed lines), (iv) linear increase of 5 points of BMI (pink lines), (v) linear increase of 10 points of BMI (green lines). For example, on the top left panel, women who had a BMI of 25kg/m2 24 years prior to the first cognitive assessment and linearly dropped to a BMI of 20kg/m2 at the initial cognitive interview (i.e. legend labelled “25 >20”) have an initial average TICS level of 33.8 points that decreases over time to 32.4 points after 7 years of follow-up

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