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Table 5 Parameters for different episode 2 non-enrolment scenarios (simulation study 2a). For all scenarios, we set \({\upalpha}^{R_2}=0.05\) and \({\upgamma}^{R_2}=0.10\)

From: Independence estimators for re-randomisation trials in multi-episode settings: a simulation study

Scenario \({\upbeta}_{X_{PL}}\) \({\upbeta}_{X_{EL}}\) \({\upbeta}_{X_{PL}}^{R_2}\) \({\upbeta}_{X_{EL}}^{R_2}\) \({\updelta}_{Xpl}^{R_2}\) \({\updelta}_{Xel}^{R_2}\)
Scenario 1 – Non-enrolment depends on previous treatment allocation 0 0 0 0 0 0
Scenario 2 – Non-enrolment depends on previous treatment allocation and previous outcome 10 0 0.25 0 0 0
Scenario 3 – Non-enrolment depends on previous treatment allocation and baseline prognosis at episode 2 0 10 0 0.25 0 0
Scenario 4 – Non-enrolment is differential between treatment groups based on previous outcome 10 0 0 0 0.5 0
Scenario 5 – Non-enrolment is differential between treatment groups based on baseline prognosis at episode 2 0 10 0 0 0 0.5