Skip to main content

Table 1 Overview of the OPUS, OrPHeUS and EXPOSURE databases

From: Standardizing registry data to the OMOP Common Data Model: experience from three pulmonary hypertension databases

  OPUS OrPHeUS EXPOSURE
Study identifier NCT02126943 NCT03197688 EUPAS19085
Study type Multi-centre, prospective drug registry of PH patients newly treated with macitentan Multi-centre, retrospective medical chart review of PH patients newly treated with macitentan Multi-centre, prospective cohort study of patients with PAH newly treated with either selexipag or any other PAH-specific therapy
Region USA USA Europe and Canada
Date ranges Apr 2014 – Apr 2020 Oct 2013 to Mar 2017 Sept 2017 – ongoinga
Patients in database, N 2722 3142 758
Age at enrolment in database, mean (SD), years [N] 60.93 (14.15)
[N = 2682]
60.21 (15.06)
[N = 3060]
59.96 (15.07)
[N = 752]
Gender, %
 Female 71.6 72.2 68.6
 Male 26.9 25.2 31.3
 Missing 1.4 2.5 0.1
Source data format
 Conditions MedDRA and free text MedDRA and free text MedDRA and free text
 Drugs WHODrug and free text WHODrug and free text WHODrug and free text
  1. aData cut-off for this analysis was 30 Nov 2019
  2. Percentages might not add up to 100.0% due to rounding
  3. MedDRA Medical Dictionary for Regulatory Activities; OPUS OPsumit® USers OrPHeUS OPsumit® Historical USers; PH pulmonary hypertension; PAH pulmonary arterial hypertension; SD standard deviation; USA United States of America; WHODrug World Health Organization Drug Dictionary