Fig. 2

Empirical correlation matrix of the pre-processed variables. Pairwise correlations of observations from all patients for 11 years (years 0, …,10 since the disease onset) are calculated and plotted using range of colors from red, white, and blue each representing correlation of 1, 0, and -1, respectively. The 11 by 11 block matrices on the diagonals show the degree of correlation in patients’ repeated observations over time for each of the four measures, and the 11 by 11 block matrices of the diagonal display the degree of correlation across different measures