Study name | Region(s) Involved | Study Inclusion & Exclusion Criteria | No. Requested by researchers | No. Identified in EHRs | No. Provided by SHARE to Research Team | No. Recruited | Percentage Identified and Recruited | Percentage Provided and Recruited | Percentage Fulfilled |
---|---|---|---|---|---|---|---|---|---|
Q | West | Inclusion: • Age: 30–75 • Healthy Exclusion: • History of peptic ulcer disease • History of Barrett’s oesophagus • Previous H. pylori eradication • Current use of PPIa/H2 blockers • PPI use within last 12 months • Upper GI cancer • Pregnancy | 150 | 1565 | 243 | 134 | 8.6 | 55.1 | 89.3 |
R | East | Inclusion: • Aged 60–85 • Fluent in English • Able to read • Reliable study partner/informant Exclusion: • Dementia or any degenerative brain disorder • Brain disease • On cholinesterase inhibitors and/or memantine • Receiving daily medications with the potential to affect cognition such as sedatives, pain medications, or anticonvulsants within 30 days • Familial autosomal dominant Alzheimer’s disease or other familial dementing diseases • Uncontrolled or untreated thyroid problems • Clinically significant vitamin B12 or folic acid deficiency • Chromosome21trisomy • History within the past 2 years or current diagnosis of significant psychiatric illness • History within the last 5 years of a serious infectious disease affecting the brain or head trauma resulting in protracted loss of consciousness • Contraindications for MRI • Major surgery, requiring general anaesthesia within 8 weeks or has not recovered • Exposure to ionizing radiation • Learning disability • Currently participating in any interventional studies • Currently participating in non-interventional study that involves exposure to radiation or neuropsychological testing • History within the last 5 years of any type of cancer • Currently on regular Vitamin B injections • Currently taking anti-seizure medications • Currently taking co-codamol or dihydrocodeine • Currently taking opioids • Currently taking benzodiazepines • Stroke • Blindness • Deafness or significant hearing impairment • Seizures | 250 | 2365 | 700 | 91 | 3.8 | 13.0 | 36.4 |
S | All | Inclusion: • Age: ≥16 years • Diagnosis within the last 20 months of type 1diabetes or non-type 1 diabetes treated with diet non-type 1 diabetes on metformin monotherapy only • Able to give informed consent Exclusion: • Non-type 1 diabetes on any oral hypoglycaemic agent other than metformin and who have had a prescription in the last 6 months • Non-type 1 diabetes treated with an injectable therapy and who have had a prescription in the last 6 months • Gestational diabetes | 6000 | 3828 | 1040 | 246 | 6.4 | 23.7 | 4.1 |
T | East | Inclusion: • Age: ≥70 • Heart Failure (NYHAb class II to IV) • On frusemide) and ACE-ic Exclusion: • Living in nursing or residential home accommodation | 30 | 99 | 36 | 19 | 19.2 | 52.8 | 63.3 |
U | East | Inclusion: • Age: > 40 • COPD Exclusion: • Implemented during investigator screening | 150 | 113 | 82 | 21 | 18.6 | 25.6 | 14.0 |
V | West | Inclusion: • Age: 20–39 Exclusion: • Insulin dependent diabetes • Diseases of the Nervous System 1 • Diseases of the Nervous System 2 • Congenital malformations of the nervous system • Inability to give informed consent • Mental retardation • Alzheimer’s Disease • Other degenerative diseases of the CNSd, not elsewhere specified • Other degenerative disorders of nervous system in diseases classified elsewhere • myotonic dystrophy or other muscular dystrophy • family history of myotonic dystrophy and never tested • Severe concurrent medical condition, e.g. cardiac failure or respiratory failure • Contraindications to MRIe • History of major head trauma with loss of consciousness greater than a few minutes or with significant medical sequelae | 8 | 66 | 10 | 7 | 10.6 | 70.0 | 87.5 |
W | East | Inclusion: • Age: 40–85 • Type 2 Diabetes • Blood pressure ≤ 140/80 mmHg • HbA1ch value ≤64 mmol/mol Exclusion: • Blood pressure > 140/80 mmHg • eGFRi < 60 • Atrial fibrillation • Heart failure • Peripheral vascular disease • Stroke • TIAj • Ischaemic heart disease • Inability to consent | 30 | 238 | 24 | 5 | 2.1 | 20.8 | 16.7 |
X | West | Inclusion: • Male or female ≥18 years of age • Residing in Scotland • Diagnosis of Bipolar Disorder • At least three months lithium treatment in the past or current lithium treatment | 190 | 16 | 6 | 6 | 37.5 | 100.0 | 3.2 |
Median (Interquartile) | 150 (30–190) | 238 (99–1565) | 82 (24–243) | 21 (7–91) | 9.8 (6.4–18.6) | 52.7 (23.7–55.1) | 36.4 (14.0–63.3) |