|
Handling verification bias
|
Without
|
With (Begg and Greenes)
|
|---|
|
Cell matrix
| | |
2×2
| |
3×2
|
3×2
|
|---|
|
Methods
|
Worst case
|
Conventional
|
Best case
|
MICE
|
Conditional
|
Conditional
|
|---|
|
Se/ Sec
|
0.848
|
0.970
|
0.974
|
0.946
|
0.970
|
0.863
|
| |
[0.82-0.87]
|
[0.96-0.98]
|
[0.96-0.98]
|
[0.93-0.96]
|
[0.96-0.98]
|
[0.84-0.884]
|
|
Sp/ Spec
|
0.946
|
0.998
|
0.998
|
0.986
|
0.998
|
0.998
|
| |
[0.93-0.96]
|
[0.99-0.99]
|
[0.99-0.99]
|
[0.98-0.99]
|
[0.99-0.99]
|
[0.991-0.999]
|
|
LR+
|
16
|
570
|
603
|
67.5
|
570
|
552
|
| |
[11.4-22.2]
|
[80.4-4,037]
|
[85-4,273]
|
[-]
|
[80.4-4,037]
|
[78-3911.5]
|
|
LR−
|
0.160
|
0.029
|
0.026
|
0.055
|
0.029
|
0.137
|
| |
[0.14-0.19]
|
[0.02-0.04]
|
[0.02-0.04]
|
[-]
|
[0.02-0.04]
|
[0.117-0.160]
|
|
Accuracy
|
0.887
|
0.982
|
0.984
|
0.962
|
0.887
|
0.837
|
| |
[0.87-0.90]
|
[0.97-0.99]
|
[0.98-0.99]
|
[0.95-0.97]
|
[0.871-0.902]
|
[0.819-0.854]
|
|
prev
|
0.608
|
0.588
|
0.608
|
0.608
|
0.608
|
0.620
|
| |
[0.583-0.632]
|
[0.561-0.612]
|
[0.583-0.632]
|
[0.583-0.632]
|
[0.583-0.632]
|
[0.597-0.643]
|
|
Y+
|
-
|
-
|
-
|
-
|
0.875
|
0.889
|
| | | | | |
[0.852-0.895]
|
[0.868-0.907]
|
|
Y−
|
-
|
-
|
-
|
-
|
0.948
|
0.952
|
| | | | | |
[0.928-0.964]
|
[0.933-0.967]
|
|
LR ±
|
-
|
-
|
-
|
-
|
2.4
|
2.5
|
| | | | | |
[1.7-3.5]
|
[1.5-3.5]
|
- Se sensitivity, Sp specificity, Sec conditional sensitivity, Spec conditional specificity, LR likelihood ratio, prev disease prevalence, Y test yield
