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Table 6 Different estimates [with 95% CI] of FNAC test performance according to the different methods

From: Statistical methods for evaluating the fine needle aspiration cytology procedure in breast cancer diagnosis

Handling verification bias Without With (Begg and Greenes)
Cell matrix    2×2   3×2 3×2
Methods Worst case Conventional Best case MICE Conditional Conditional
Se/ Sec 0.848 0.970 0.974 0.946 0.970 0.863
  [0.82-0.87] [0.96-0.98] [0.96-0.98] [0.93-0.96] [0.96-0.98] [0.84-0.884]
Sp/ Spec 0.946 0.998 0.998 0.986 0.998 0.998
  [0.93-0.96] [0.99-0.99] [0.99-0.99] [0.98-0.99] [0.99-0.99] [0.991-0.999]
LR+ 16 570 603 67.5 570 552
  [11.4-22.2] [80.4-4,037] [85-4,273] [-] [80.4-4,037] [78-3911.5]
LR 0.160 0.029 0.026 0.055 0.029 0.137
  [0.14-0.19] [0.02-0.04] [0.02-0.04] [-] [0.02-0.04] [0.117-0.160]
Accuracy 0.887 0.982 0.984 0.962 0.887 0.837
  [0.87-0.90] [0.97-0.99] [0.98-0.99] [0.95-0.97] [0.871-0.902] [0.819-0.854]
prev 0.608 0.588 0.608 0.608 0.608 0.620
  [0.583-0.632] [0.561-0.612] [0.583-0.632] [0.583-0.632] [0.583-0.632] [0.597-0.643]
Y+ - - - - 0.875 0.889
      [0.852-0.895] [0.868-0.907]
Y - - - - 0.948 0.952
      [0.928-0.964] [0.933-0.967]
LR ± - - - - 2.4 2.5
      [1.7-3.5] [1.5-3.5]
  1. Se sensitivity, Sp specificity, Sec conditional sensitivity, Spec conditional specificity, LR likelihood ratio, prev disease prevalence, Y test yield