Table 4 Application of the Following Methods to a Real Phase III Dataset

MI-RD

−40.58

[−43.92, −37.24]

<.0001

MMRM (off-treatment visits were set to missing, i.e. "hypothetical")

−50.33

[−53.23, −47.43]

<.0001

RTB (off-treatment visits were set to missing and hence imputed)

−38.97

[−41.90, −36.04]

<.0001

MMRM (including off-treatment visits, i.e. "TP")

−43.29

[−46.10, −40.49]

<.0001

J2R

−36.59

[−39.85, −33.1]

<.0001

Mehrotra’s control-based

−37.62

[−40.36, −34.88]

<.0001

Trimmed Means

−51.41

[−55.55, −47.27]

<.0001