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Table 4 Application results

From: Weighted composite time to event endpoints with recurrent events: comparison of three analytical approaches

Weighting scheme

p-value ∗

Estimator ∗∗

 

Wei-Lachin

Rauch

Bakal

Wei-Lachin

Rauch

Weight for death: 1

0.34

0.10

0.40

1.05

1.38

Weight for readmission: 1

     

Weight for death: 1

0.29

0.09

0.39

1.07

1.39

Weight for readmission: 0.9

     

Weight for death: 1

0.21

0.07

0.37

1.11

1.40

Weight for readmission: 0.7

     

Weight for death: 1

0.14

0.05

0.32

1.17

1.42

Weight for readmission: 0.5

     

Weight for death: 1

0.09

0.04

0.23

1.25

1.43

Weight for readmission: 0.3

     

Weight for death: 1

0.05

0.03

0.05

1.36

1.44

Weight for readmission: 0.1

     
  1. ∗one-sided test in favour of no chemotherapy; ∗∗ estimated weighted composite effect at end of study period for chemotherapy vs. no chemotherapy; composite endpoint = (recurrent) hospitalization plus death
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BMC Medical Research Methodology

ISSN: 1471-2288

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