Fig. 1
From: Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic
Left: Prior dose-toxicity relationship for σ1 = 1.10, σ2 = 0.30, with μ2 = − 0.15, ν = 0.05 (solid line), and μ2 = 0.15, ν = 0.15 (dashed line). The horizontal line is the target toxicity level (note the toxicity on the control arm is not exactly 10% as this is the mean of a nonlinear transformation). Right: Bounds of the prior 95% credible interval around prior toxicity estimates for μ2 = − 0.05, ν = 0.075 with σ1 = 0.80, σ2 = 0.10 (dashed lines) and σ1 = 1.20, σ2 = 0.50 (dotted lines)