Table 7 HIGH clinical trial: Detection of treatmen-by-subset interaction when K=3
\(\boldsymbol {\widehat {\theta }}\)global CI95% | \(\boldsymbol {\widehat {\theta _{A}}}\)CI95% | \(\boldsymbol {\widehat {\theta _{B}}}\)CI95% | \(\boldsymbol {\widehat {\theta _{C}}}\)CI95% | Decision | nA | nB | nC | Proportion interaction effect* | |
|---|---|---|---|---|---|---|---|---|---|
Age Partition | Age≤58 | 58<Age≤68 | Age>68 | ||||||
1er interim analysis | 1.062[0.484-1.972] | 0.804[0.444-1.280] | 1.558[0.806-2.969] | Go with entire population | 61 | 74 | 59 | 0.21& 0.46 | |
2nd interim analysis | 0.913[0.518-1.493] | 0.979[0.612-1.450] | 1.437[0.920-2.217] | Go with entire population | 127 | 135 | 126 | 0.10& 0.12 | |
3th interim analysis | 0.755[0.475-1.108] | 0.975[0.670-1.381] | 1.086[0.782-1.485] | Go with entire population | 197 | 202 | 186 | 0.01& 0.00 | |
Final analysis | 0.993[0.823-1.18] | 0.850[0.570-1.209] | 0.986[0.719-1.334] | 1.141[0.838-1.499] | Go with entire population | 255 | 268 | 253 | 0.00& 0.00 |