Skip to main content
Fig. 33 | BMC Medical Research Methodology

Fig. 33

From: Analysis approaches to address treatment nonadherence in pragmatic trials with point-treatment settings: a simulation study

Fig. 33

Mean squared error (MSE) versus the nonadherence rate using DAG 1 for 500 samples. The naïve 2SLS and 2SRI share the same line, the first stage adjusted 2SLS and 2SRI share the same line, and both-stages adjusted 2SLS and 2SRI share the same line as they produce approximately the same MSE. The first stage adjusted 2SLS and 2SRI, and naïve PP produce MSEs larger than 0.15 for strong unmeasured confounders so that the MSE is out of the bound [0, 0.15]. Abbreviations: ITT: intention-to-treat, PP: per-protocol, AT: as-treated, IP-weighted PP: inverse probability-weighted per-protocol, 2SLS: two-stage least square, 2SRI: two-stage residual inclusion

Back to article page

BMC Medical Research Methodology

ISSN: 1471-2288

Contact us