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Fig. 9 | BMC Medical Research Methodology

Fig. 9

From: Analysis approaches to address treatment nonadherence in pragmatic trials with point-treatment settings: a simulation study

Fig. 9

95% coverage probability versus the nonadherence rate using DAG 1. The naïve 2SLS and 2SRI share the same line, the first-stage adjusted 2SLS and 2SRI share the same line, and both-stages adjusted 2SLS and 2SRI share the same line as they produce approximately the same coverage probability. Abbreviations: ITT: intention-to-treat, PP: per-protocol, AT: as-treated, IP-weighted PP: inverse probability-weighted per-protocol, 2SLS: two-stage least square, 2SRI: two-stage residual inclusion

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