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Table 3 The nonadherence rates per arm for different choices of α0 for simulation settings 1-3 with (α1,α2,α3,α4)=(0.6,0.4,0.35,0) for setting 1, (0.25,0.02,0.04,0.05) for setting 2, and (0,0.01,0.04,0) for setting 3

From: Analysis approaches to address treatment nonadherence in pragmatic trials with point-treatment settings: a simulation study

Scenario

Arm

A. Setting 1

B. Setting 2

C. Setting 3

  

α0

Nonadherence

α0

Nonadherence

α0

Nonadherence

1

Z = 1

0.72

10

0.55

11

0.86

10

 

Z = 0

-4.06

10

0.02

11

0.06

10

2

Z = 1

-0.23

20

0.46

20

0.76

20

 

Z = 0

-3.14

20

0.12

21

0.16

20

3

Z = 1

-1.47

40

0.25

41

0.56

41

 

Z = 0

-1.92

40

0.32

41

0.36

40

4

Z = 1

-2.52

60

0.05

61

0.36

60

 

Z = 0

-0.85

60

0.52

61

0.57

60

5

Z = 1

-3.76

80

-0.15

81

0.16

80

 

Z = 0

0.39

80

0.70

80

0.77

80

6

Z = 1

-4.72

90

-0.25

91

0.06

90

 

Z = 0

1.35

90

0.80

89

0.86

90