a) Review: multiplicity approach taken | ||||
 | Formal adjustment | Hierarchical testing | Other approach | None |
Subgroup analyses | 8/85a (9%) | 0/85 (0%) | 0/85 (0%) | 77/85b (91%) |
b) Survey: responses to posed scenarios | ||||
 | Yes | No | Unsure | |
Would you consider adjusting for multiplicity arising from performing multiple subgroup analyses? | 6/27 (22%) | 17/27 (63%) | 4/27 (15%) | |
Consider a parallel group trial with multiple subgroup analyses performed. Would you adjust for multiplicity in the following scenarios? | Â | Â | Â | |
Subgroup analyses pre-specified in the study protocol? | 3/27 (11%) | 22/27 (81%) | 2/27 (7%) | |
Subgroup analyses determined post-hoc? | 4/27 (15%) | 22/27 (81%) | 1/27 (4%) | |
Subgroup analyses specified for the following reasons: a) to confirm biological plausibility, b) to confirm existing hypotheses, AND c) to show subgroup effects for supporting decision making in target populations. | 3/27 (11%) | 19/27 (70%) | 5/27 (19%) | |
Would you be more likely to adjust for multiplicity if the number of subgroup analyses was increased? | 5/27 (19%) | 21/27 (78%) | 1/27 (4%) |