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Table 4 Performances of our proposed meta-analysis method (BACON adjusted Weighted Z) and the other methods in comparison under reduced differential expressions between subject groups and varying experiment sample sizes

From: Robust meta-analysis for large-scale genomic experiments based on an empirical approach

Setting Method Performance assessment measure
Sensitivity Specificity FDR FNR
1 Fisher 1.00 0.99 0.05 0.00
EAMA 1.00 0.99 0.09 0.00
BACON adjusted Fisher 1.00 0.99 0.05 0.00
weighted Z 1.00 0.99 0.05 0.00
EB adjusted weighted Z 1.00 0.99 0.06 0.00
BACON adjusted weighted Z 1.00 1.00 0.05 0.00
2 Fisher 0.44 0.13 0.95 0.34
EAMA 0.40 1.00 0.003 0.34
BACON adjusted Fisher 0.40 1.00 0.02 0.06
weighted Z 0.55 0.01 0.94 0.84
EB adjusted weighted Z 1.00 1.00 0.04 0.00
BACON adjusted weighted Z 1.00 1.00 0.02 0.00
3 Fisher 0.99 1.00 0.05 0.00
EAMA 0.99 1.00 0.02 0.00
BACON adjusted Fisher 0.99 1.00 0.02 0.00
weighted Z 1.00 1.00 0.05 0.00
EB adjusted weighted Z 1.00 1.00 0.03 0.00
BACON adjusted weighted Z 1.00 1.00 0.02 0.00