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Table 3 Estimated mean BMC growth velocity during different age windows from the selected linear spline LME models

From: Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

 

Grams per year change in BMC [(mean (95% CI)]

ALSPAC

BMDCS

PBMAS

Females

 8.8y to 11.4y (ALSPAC); 5.0y to 7.9y (BMDCS); 7.9y to 14.2y (PBMAS)

177.7 (173.8 to 181.6)

67.6 (60.1 to 75.1)

195.4 (189.7 to 201.1)

 11.4y to 13.9y (ALSPAC); 7.9y to 10.7y (BMDCS); 14.2y to 20.5y (PBMAS)

238.9 (236.0 to 241.7)

84.1 (79.0 to 89.2)

34.7 (30.0 to 39.5)

 13.9y to 16.4y (ALSPAC); 10.7y to 13.6y (BMDCS); 20.5y to 26.9y (PBMAS)

117.3 (113.2 to 121.3)

189.0 (184.7 to 193.3)

−3.3 (− 7.5 to 0.9)

 16.4y to 18.9y (ALSPAC); 13.6y to 16.4y (BMDCS); 26.9y to 33.2y (PBMAS)

5.0 (−1.3 to 11.3)

85.7 (80.1 to 91.3)

9.1 (3.0 to 15.1)

 18.9y to 21.5y (ALSPAC); 16.4y to 19.3y (BMDCS); 33.2y to 39.5y (PBMAS)

99.2 (74.2 to 124.2)

17.4 (10.6 to 24.1)

5.2 (−5.9 to 16.3)

 21.5y to 24.0y (ALSPAC); 19.3y to 22.1y (BMDCS)

20.1 (− 7.0 to 47.2)

19.5 (11.1 to 27.8)

–

 24.0y to 26.5y (ALSPAC)

15.2 (3.0 to 27.5)

–

–

Males

 8.8y to 12.3y (ALSPAC); 5.0y to 8.6y (BMDCS); 7.8y to 12.5y (PBMAS)

148.5 (144.2 to 150.8)

70.2 (61.7 to 78.7)

157.5 (144.2 to 170.8)

 12.3y to 15.9y (ALSPAC); 8.6y to 12.3y (BMDCS); 12.5y to 17.1y (PBMAS)

305.6 (302.5 to 308.8)

107.4 (101.7 to 113.1)

247.1 (238.7 to 255.4)

 15.9y to 19.4y (ALSPAC); 12.3y to 16.0y (BMDCS); 17.1y to 21.7y (PBMAS)

103.3 (98.6 to 108.0)

253.2 (248.4 to 258.0)

19.3 (8.9 to 29.7)

 19.4y to 23.0y (ALSPAC); 16.0y to 19.6y (BMDCS); 21.7y to 26.3y (PBMAS)

93.5 (84.1 to 102.8)

71.4 (63.3 to 79.5)

11.2 (0.8 to 21.6)

 23.0y to 26.5y (ALSPAC); 19.6y to 23.3y (BMDCS); 26.3y to 31.0y (PBMAS)

11.7 (−6.4 to 29.9)

8.0 (−3.5 to 19.6)

10.7 (−1.5 to 22.8)

 31.0y to 35.6y (PBMAS)

–

–

−7.9 (−26.4 to 10.7)

 35.6y to 40.2y (PBMAS)

–

–

−0.4 (−32.7 to 32.0)

  1. Age windows are defined by the number and position of the knots, which were placed at quantiles of the age distribution