Table 1 Assumptions of the paired diagnostic accuracy trial for the comparison of the experimental Positron Emission Tomography (PET) combined with the computed tomography (CT) against the comparator test PET
From: Blinded sample size re-estimation in a comparative diagnostic accuracy study
General input parameters: Significance level per endpoint: \(\boldsymbol{\alpha} =\mathbf{0.05}\ \left(\mathsf{two}-\mathsf{sided}\right),\)  Overall Power: Poweroverall = 1 − βoverall = 0.8 Power per endpoint: PowerSe = PowerSp = 1 − βSe = 1 − βSp = 0.9 | |||
|---|---|---|---|
Prevalence: π = 0.47 | Comparator test (CT) | Experimental test (PET/CT) | Proportion of discordant test results |
Diseased population | SeC = 0.81 | SeE = 0.90 | ψ D = 0.09 |
Non-diseased population | SpC = 0.66 | SpE = 0.80 | ψ ND = 0.14 |