Table 4 Different number of interims investigated
From: Bayesian adaptive design for pediatric clinical trials incorporating a community of prior beliefs
Number of interims | Timing of planned interims (number of patients enrolled) |
|---|---|
0 | NA (Full accrual up to 256, no interim analysis) |
1 | 128 |
2 | 85 170 |
3 | 64 128 192 |
4 | 51 102 153 204 |
5 | 43 86 129 172 215 |
6 | 37 74 110 146 183 220 |
7 | 32 64 96 128 160 192 224 |
8 | 28 56 84 112 140 168 196 224 |
9 | 25 50 75 100 125 150 175 200 225 |
10 | 23 46 69 92 115 138 161 184 207 230 |
12 | 20 40 60 80 100 120 140 160 180 200 220 240 |
14 | 17 34 51 68 85 102 119 136 153 170 187 204 221 238 |
18 | 13 26 39 52 65 78 91 104 117 130 143 156 169 182 195 208 221 234 |