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Table 1 Case-mix characteristics of patients treated in all 17 EVT hospitals in the Netherlands; stratified by whether patients received IVT or not and whether patients underwent GA or not

From: Estimation of treatment effects in observational stroke care data: comparison of statistical approaches

 

hospitals range

(n = 17)

P-valuesb

IVT +

(n = 2450)

IVT -

(n = 817)

P-valuesb

GA + 

(n = 778)

GA -

(n = 2304)

P-valuesc

Age (years) [Median (IQR)]

68–77

0.001

71 (60–80)

73 (63–82)

< 0.001

70 (59–79)

73 (62–81)

< 0.001

Baseline NIHSS score [Median (IQR)]

13–17

< 0.001

16 (11–19)

16 (11–20)

0.048

17 (12–20)

16 (11–19)

0.011

Time from onset to arrival at the ED (min) [Median (IQR)]

52–160

< 0.001

135 (65–185)

145 (67–240)

< 0.001

140 (72–190)

135 (64–195)

0.538

Men [N (%)]

39–55%

0.790

1294 (53)

394 (48)

0.024

420 (54)

1178 (51)

0.171

Medical History [N (%)]

 Previous Stroke

0–26%

< 0.001

330 (14)

212 (26)

< 0.001

127 (16)

389 (17)

0.739

 Atrial Fibrillation

13–37%

< 0.001

414 (17)

356 (44)

< 0.001

157 (20)

567 (25)

0.012

 Hypertension

41–67%

< 0.001

1234 (50)

447 (55)

0.037

346 (45)

1251 (54)

< 0.001

 Hypercholesterolemia

15–50%

< 0.001

696 (28)

269 (33)

0.023

207 (27)

720 (31)

< 0.001

Good functional outcomea [N (%)]

31–50%

0.004

985 (40)

251 (30)

< 0.001

272 (35)

896 (39)

0.309

IVT utilization [N (%)]

66–87%

< 0.001

 

GA utilization [N (%)]

0–99%

< 0.001

Hospital volume [n]

23–405

 
  1. IVT Intravenous thrombolysis, GA general anesthesia, NIHSS National institutes of health stroke scale, ED Emergency department
  2. a Good functional outcome is defined as mRS 0–2 at 90 days
  3. b P-value is based on comparison between 17 centers using a non-parametric Kruskal Wallis test for continuous variables or Pearson’s chi-square statistic for categorical variables
  4. c P-value is based on comparison between groups (receiving IVT/GA vs. non-receiving IVT/GA) using a non-parametric Kruskal Wallis test for continuous variables or Pearson’s chi-square statistic for categorical variables