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Table 5 Marginal estimates of 5-year RS and LLE for all investigated settings and scenarios. Marginal point estimates (PE) of 5-year relative survival (RS) and loss in life expectancy (LLE), with lower (LCI) and upper (UCI) confidence intervals, standard errors (SE) and relative % precision (RP) from different methods, settings and scenarios for including uncertainty in the general population mortality when estimating SEs. For settings 1 and 1S general population mortality rates are stratified by age, sex and calendar year. For settings 2 and 2S general population mortality rates are stratified by age, sex, calendar year and region. RP illustrates comparison of the conventional method to a bootstrap-based method

From: Assessing the impact of including variation in general population mortality on standard errors of relative survival and loss in life expectancy

Method Setting / scenariob 5-year Relative Survival (RS) Loss in life expectancy (LLE)a
   PE SE LCI UCI RPc PE SE LCI UCI RP
Conventionald 1 0.632 0.011 0.611 0.654 0.00 5.40 0.16 5.09 5.71 0.00
Bootstrap-basede A 0.632 0.011 0.611 0.654 0.01 5.40 0.16 5.09 5.71 0.11
  B 0.632 0.011 0.611 0.654 0.16 5.40 0.16 5.08 5.71 1.08
  C 0.632 0.011 0.610 0.655 3.08 5.40 0.17 5.06 5.74 21.82
  D 0.632 0.013 0.608 0.658 30.55 5.40 0.28 4.85 5.95 214.25
Conventional 2 0.631 0.011 0.610 0.653 0.00 5.40 0.16 5.09 5.71 0.00
Bootstrap-based F 0.631 0.011 0.610 0.653 0.02 5.40 0.16 5.09 5.71 0.11
  G 0.631 0.011 0.610 0.653 0.15 5.40 0.16 5.09 5.72 1.09
  H 0.631 0.011 0.609 0.654 3.07 5.41 0.18 5.07 5.76 22.41
  I 0.631 0.013 0.606 0.656 30.06 5.58 0.32 4.95 6.21 313.01
Conventional 1Sf 0.619 0.037 0.550 0.695 0.00 5.19 0.51 4.19 6.19 0.00
Bootstrap-based E 0.619 0.037 0.550 0.695 0.02 5.19 0.51 4.19 6.19 0.11
Conventional 2Sf 0.617 0.037 0.549 0.693 0.00 5.19 0.51 4.19 6.19 0.00
Bootstrap-based J 0.616 0.037 0.549 0.693 -0.01 5.19 0.51 4.19 6.19 0.15
  1. aLLE is presented in years
  2. bSee Table 1 for information on the different settings and scenarios
  3. cRP is presented in %
  4. dConventional refers to the standard method for estimating SEs, where the general population mortality is assumed to be measured without uncertainty
  5. eBootstrap-based refers to the parametric bootstrap approach used for including uncertainty in population mortality rates in the estimation of SEs
  6. fS stands for small and refers to the setting to investigate what would be observed for a smaller population
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BMC Medical Research Methodology

ISSN: 1471-2288

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