Fig. 2

Kaplan–Meier curves for time to death (cumulative incidence) from time of entry to four progressive exacerbation states arising post-randomisation (mITT population). Since time is measured from state entry, and the majority of patients are in the state of no exacerbation at study entry, the number at risk is much higher at 12 months for the no exacerbation state compared with the other exacerbation states. exac exacerbation, mITT modified intent-to-treat, mod moderate, sev severe