Table 2 Hazard ratios comparing risks of death and ≥ 1 severe exacerbation among the different states based on the best fitting Weibull multi-state Markov model without adjustment for covariates (mITT population)
Transition to death from | vs transition to death from | HR | SE | 95% CI |
|---|---|---|---|---|
State 2 (1 moderate exacerbation) | State 1 (No exacerbation) | 1.8 | 0.3 | (1.1–2.9) |
State 3 (≥ 2 moderate exacerbations) | State 1 (No exacerbation) | 2.1 | 0.3 | (1.1–3.9) |
State 3 (≥ 2 moderate exacerbations) | State 2 (1 moderate exacerbation) | 1.2 | 0.4 | (0.6–2.4) |
State 4 (≥ 1 severe exacerbations) | State 1 (No exacerbation) | 11.4 | 0.2 | (7.7–17.0) |
State 4 (≥ 1 severe exacerbations) | State 2 (1 moderate exacerbation) | 6.4 | 0.3 | (3.8–10.8) |
State 4 (≥ 1 severe exacerbations) | State 3 (≥ 2 moderate exacerbations) | 5.4 | 0.3 | (2.9–10.3) |
Transition to ≥ 1 severe exacerbation from | vs transition to ≥ 1 severe exacerbation from |  |  |  |
State 2 (1 moderate exacerbation) | State 1 (No exacerbation) | 1.4 | 0.1 | (1.2–1.6) |
State 3 (≥ 2 moderate exacerbations) | State 1 (No exacerbation) | 1.9 | 0.1 | (1.6–2.3) |
State 3 (≥ 2 moderate exacerbations) | State 2 (1 moderate exacerbation) | 1.4 | 0.1 | (1.1–1.7) |