Table 3 Estimated transition probabilities from baseline to 4Â weeks based on the Weibull multi-state model using the Markov assumptiona and fitted without covariates, reported per 10,000 patients (mITT population)
From exacerbation state | To exacerbation state | ||||
|---|---|---|---|---|---|
State 1 (No exacerbation) | State 2 (1 moderate exacerbation) | State 3 (≥ 2 moderate exacerbations) | State 4 (≥ 1 severe exacerbations) | State 5 (Death) | |
State 1 (No exacerbation) | 9085 (9027–9136) | 693 (655–734) | 61 (53–70) | 147 (134–161) | 15 (12–18) |
State 2 (1 moderate exacerbation) | 0 (0–0) | 8256 (8115–8383) | 1514 (1396–1632) | 205 (176–238) | 25 (18–37) |
State 3 (≥ 2 moderate exacerbations) | 0 (0–0) | 0 (0–0) | 9696 (9636–9747) | 274 (227–330) | 29 (17–50) |
State 4 (≥ 1 severe exacerbations) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 9851 (9795–9894) | 149 (106–205) |
State 5 (Death) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 10,000 (10,000–10,000) |