A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloroquine with an 11-year follow-up

Sabatier, P.; Wack, M.; Pouchot, J.; Danchin, N.; Jannot, AS.

doi:10.1186/s12874-022-01628-3

Table 3 HCQ adverse drug reactions know

From: A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloroquine with an 11-year follow-up

Localization	Adverse effect	Frequency	Related association signals
Gastrointestinal disorders	Abdominal pain, nausea	Very common	metopimazine
Gastrointestinal disorders	Diarrhea, vomiting	Common	metopimazine
Eye disorders	Blurring of vision due to a disturbance of accommodation	Common	eyes procedures
	Retinopathy with changes in pigmentation and visual field defects	Uncommon	eyes procedures
	Cases of maculopathies and macular degeneration have been reported	Not known	eyes procedures
Cardiac disorders	Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome	Not known	No signal
Ear and labyrinth disorders	Vertigo, tinnitus	Uncommon	No signal
Ear and labyrinth disorders	Hearing loss	Not known	No signal
Nervous system disorders	Headache	Common	No signal
	Dizziness	Uncommon	No signal
	Convulsions have been reported with this class of drugs	Not known	No signal
Psychiatric disorders	Affect lability	Common	No signal
	Nervousness	Uncommon	No signal
	Psychosis	Not known	No signal
Immune system disorders	Urticaria, angioedema, bronchospasm	Not known	No signal
Blood and Lymphatic system disorders	Bone-marrow depression, anemia, aplastic anemia, agranulocytosis, leucopenia and thrombocytopenia	Not known	No signal
Hepatobiliary disorders	Abnormal liver function tests	Uncommon	No signal
Hepatobiliary disorders	Fulminant hepatic failure	Not known	No signal
Skin and subcutaneous tissue disorders	Skin rash, pruritus	Common	No signal
	Pigmentation disorders in skin and mucous membranes, bleaching of hair, alopecia	Uncommon	No signal
	Bullous eruptions including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis, Drug Rash with Eosinophilia and Systemic Symptoms, photosensitivity, exfoliative dermatitis, acute generalised exanthematous pustulosis	Not known	No signal
Musculoskeletal and connective tissue disorders	Skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups	Not known	No signal
Metabolism and nutrition disorders	Anorexia	Common	No signal
Metabolism and nutrition disorders	Hypoglycemia	Unknown	No signal

Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < 1/100), Rare (≥ 1/10,000 to < 1/1,000), Very rare (< 1/10,000), not known (cannot be estimated from the available data)

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ISSN: 1471-2288

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