Table 4 Originally reported effect sizes compared to revised effect sizes derived from the adjusted analysis
From: Risk of selection bias assessment in the NINDS rt-PA stroke study
Time Stratum | Endpoint | Reported Effect Size | Revised Effect Size |
|---|---|---|---|
0-90 Min (N = 302) | Barthel Index | OR 1.8 (1.2-2.9), p = .010 | aOR 1.7 (1.1 – 2.8), p = .020 |
Modified Rankin Scale | OR 1.7 (1.0-2.6), p = .035 | aOR 1.6 (1.0-2.6), p = .059 | |
Glasgow Outcome Scale | OR 1.6 (1.0-2.5), p = .057 | aOR 1.5 (.9- 2.4), p = .097 | |
NIHSS | OR 2.0 (1.2-3.4), p = .008 | aOR 1.9 (1.1 – 3.3), p = .018 | |
91-180 Min (N = 322) | Barthel Index | OR 1.6 (1.1-2.5), p = .026 | aOR 1.5 (.9-2.5), p = .136 |
Modified Rankin Scale | OR 2.4 (1.5-3.7), p < .001 | aOR 2.3 (1.3 – 4.0), p = .003 | |
Glasgow Outcome Scale | OR 2.0 (1.3-3.2), p = .002 | aOR 1.9 (1.1 – 3.2), p = .019 | |
NIHSS | OR 2.0 (1.2-3.2), p = .008 | aOR 1.6 (.9 – 2.8), p = .114 |