Assessing the ability of an instrumental variable causal forest algorithm to personalize treatment evidence using observational data: the case of early surgery for shoulder fracture

Brooks, John M.; Chapman, Cole G.; Floyd, Sarah B.; Chen, Brian K.; Thigpen, Charles A.; Kissenberth, Michael

doi:10.1186/s12874-022-01663-0

Table 4 Third-level Split Ex-Post Reference Class Designations by Minimum Leaf Node Size in IV-CFA Estimation on the Detriment Outcome for Medicare Patients with Proximal Humerus Fractures in 2011 with 4000 Trees in the Forest

From: Assessing the ability of an instrumental variable causal forest algorithm to personalize treatment evidence using observational data: the case of early surgery for shoulder fracture

	Third-level Split Nodes
Minimum Leaf Size	Lowest ← Early Surgery Effect on Detriment Outcome → Highest
50	CCI ≤ 2, Lowest pre cost quintile, FRI > 0	CCI ≤ 2, Not lowest pre cost quintile, FRI ≤ 1	CCI > 6, Highest pre cost quintile	CCI ≤ 2, Not lowest pre cost quintile, FRI > 1	CCI > 6, Not highest pre cost quintile	2 < CCI ≤ 6, 70 +	CCI ≤ 2, Lowest pre cost quintile, FRI = 0	2 < CCI ≤ 6, < 70
100	CCI > 6, Highest pre cost quintile	CCI ≤ 2, Not lowest pre cost quintile, FRI ≤ 1	CCI ≤ 2, Lowest pre cost quintile, FRI > 0	CCI ≤ 2, Not lowest pre cost quintile, FRI > 1	2 < CCI ≤ 6, Highest pre cost quintile	CCI > 2, Not highest pre cost quintile, < 86	CCI ≤ 2, Lowest pre cost quintile, FRI = 0	CCI > 2, Not highest pre cost quintile, 86 +
200	CCI ≤ 2, Not lowest pre cost quintile, FRI ≤ 1	CCI > 6, Highest pre cost quintile	CCI ≤ 2, Lowest pre cost quintile, FRI > 0	CCI ≤ 2, Not lowest pre cost quintile, FRI > 1	2 < CCI ≤ 6, Highest pre cost quintile	CCI > 2, Not highest pre cost quintile, < 86	CCI ≤ 2, Lowest pre cost quintile, FRI = 0	CCI > 2, Not highest pre cost quintile, 86 +
300	CCI ≤ 2, Not lowest pre cost quintile, FRI ≤ 1	CCI > 6, Highest pre cost quintile	CCI ≤ 2, Lowest pre cost quintile, FRI > 0	CCI ≤ 2, Not lowest pre cost quintile, FRI > 1	2 < CCI ≤ 6, Highest pre cost quintile	CCI > 2, Not highest pre cost quintile, < 86	CCI ≤ 2, Lowest pre cost quintile, FRI = 0	CCI > 2, Not highest pre cost quintile, 86 +
400	CCI ≤ 2, Not lowest pre cost quintile, FRI ≤ 1	CCI > 6, Highest pre cost quintile	CCI ≤ 2, Lowest pre cost quintile, FRI > 0	CCI ≤ 2, Not lowest pre cost quintile, FRI > 1	2 < CCI ≤ 6, Highest pre cost quintile	CCI > 2, Not highest pre cost quintile, < 86	CCI ≤ 2, Lowest pre cost quintile, FRI = 0	CCI > 2, Not highest pre cost quintile, 86 +

CCI: Charlson Comorbidity Index score based on Medicare claims in the year prior to index proximal humerus fracture
FRI: Frailty Risk Index score based on Medicare claims in the year prior to index proximal humerus fracture
Cost Quintiles: Based on Medicare spending in the 365 days prior to the index PHF
Detriment: 1 the patient died or had an adverse event during the period 61–365 days following the index PHF, 0 otherwise. Adverse events include pneumonia, cardiac dysrhythmias, congestive heart failure, deep vein thrombosis or pulmonary embolism, infection, nerve injury, prosthetic complication, hematoma, avascular necrosis, adhesive capsulitis, and instability or dislocation

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ISSN: 1471-2288

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