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Table 1 Baseline characteristic of the MIMIC-IV cohorts

From: Machine learning approach for the prediction of 30-day mortality in patients with sepsis-associated encephalopathy

Variables

Survival

(n = 5762)

Death

(n = 1232)

P Value

Demographics

 Age (y), median [Q1, Q3]

70.00 (58.00,81.00)

77.00 (66.00,85.25)

 < 0.001

 Male, n (%)

3181 (55.21)

659 (53.49)

0.286

 Race, n (%)

  

0.001

 Black

490 (8.50)

93 (7.55)

 

 White

4000 (69.42)

824 (66.88)

 

 Hispanic

174 (3.02)

31 (2.52)

 

 Asian

193 (3.35)

31 (2.52)

 

 Others

905 (15.71)

253 (20.54)

 

Coexisting disorders, n (%)

 Myocardial infarction

1006 (17.46)

265 (21.51)

0.001

 Congestive heart failure

1977 (34.31)

540 (43.83)

 < 0.001

 Peripheral vascular disease

696 (12.08)

174 (14.12)

0.054

 Cerebrovascular disease

259 (4.49)

51 (4.14)

0.636

 Dementia

300 (5.21)

81 (6.57)

0.064

 Chronic pulmonary disease

1728 (29.99)

421 (34.17)

0.004

 Rheumatic disease

234 (4.06)

79 (6.41)

 < 0.001

 Peptic ulcer disease

229 (3.97)

64 (5.19)

0.063

 Mild liver disease

709 (12.30)

242 (19.64)

 < 0.001

 Diabetes without complication

1308 (22.70)

255 (20.70)

0.135

 Diabetes with complication

507 (8.80)

105 (8.52)

0.798

 Paraplegia

124 (2.15)

17 (1.38)

0.101

 Renal disease

1349 (23.41)

387 (31.41)

 < 0.001

 Malignant cancer

839 (14.56)

342 (27.76)

 < 0.001

 Severe liver disease

225 (3.90)

93 (7.55)

 < 0.001

 Metastatic solid tumor

343 (5.95)

205 (16.64)

 < 0.001

 AIDS

41 (0.71)

10 (0.81)

0.849

 CCI, median [Q1, Q3]

6.00 (4.00,8.00)

7.00 (6.00,9.00)

 < 0.001

Vital signs (1st 24 h)

 Temperature (°C), median [Q1, Q3]

36.90 (36.60,37.30)

36.70 (36.40,37.10)

 < 0.001

 MAP (mmHg), median [Q1, Q3]

75.00 (70.00,82.00)

73.00 (68.00,80.00)

 < 0.001

 Heart rate (min), median [Q1, Q3]

88.00 (77.00,100.00)

91.00 (80.00,104.00)

 < 0.001

 Respiratory rate (min), median [Q1, Q3]

20.00 (17.00,23.00)

22.00 (19.00,25.00)

 < 0.001

Laboratory findings (1st 24 h)

 RBC (× 109/L), median [Q1, Q3]

3.41 (3.02,3.92)

3.28 (2.88,3.80)

 < 0.001

 WBC (× 109/L), median [Q1, Q3]

11.80 (8.60,16.03)

12.62 (8.77,17.50)

0.002

 MCH (pg), median [Q1, Q3]

30.20 (28.73,31.50)

30.12 (28.70,31.63)

0.925

 MCHC (%), median [Q1, Q3]

33.00 (31.85,34.00)

32.40 (31.30,33.50)

 < 0.001

 MCV (fL), median [Q1, Q3]

91.00 (87.00,95.00)

92.75 (88.00,97.33)

 < 0.001

 PLT (× 109/L), median [Q1, Q3]

197.00 (139.00,268.50)

189.33 (116.71,272.75)

0.001

 RDW (%), median [Q1, Q3]

14.77 (13.73,16.27)

16.00 (14.58,18.00)

 < 0.001

 HCT (%), median [Q1, Q3]

31.30 (27.78,35.70)

30.38 (26.80,35.07)

 < 0.001

 APTT (s), median [Q1, Q3]

31.90 (27.80,39.80)

35.70 (29.30,49.50)

 < 0.001

 PT (s), median [Q1, Q3]

14.27 (12.85,16.50)

15.70 (13.40,20.00)

 < 0.001

 INR, median [Q1, Q3]

1.30 (1.15,1.50)

1.40 (1.20,1.85)

 < 0.001

 pH, median [Q1, Q3]

7.37 (7.32,7.42)

7.36 (7.31,7.42)

 < 0.001

 Bicarbonate (mmol/L), median [Q1, Q3]

23.00 (20.50,26.00)

21.90 (19.00,25.50)

 < 0.001

 Lactate (mmol/L), median [Q1, Q3]

1.65 (1.20,2.28)

1.95 (1.40,2.89)

 < 0.001

 BE (mEq/L), median [Q1, Q3]

-0.50 (-3.50,1.43)

-1.33 (-5.00,1.00)

 < 0.001

Aniongap (mmol/L), median [Q1, Q3]

14.00 (12.00,16.50)

15.50 (13.00,18.21)

 < 0.001

 PaO2 (mmHg), median [Q1, Q3]

112.00 (76.00,173.00)

92.00 (68.00,131.00)

 < 0.001

 PaCO2 (mmHg), median [Q1, Q3]

41.00 (37.00,47.00)

41.00 (35.00,48.00)

0.014

 Chloride (mmol/L), median [Q1, Q3]

104.50 (100.50,108.20)

103.00 (98.75,107.50)

 < 0.001

 Calcium (mmol/L), median [Q1, Q3]

8.20 (7.73,8.63)

8.10 (7.63,8.65)

0.097

 Sodium (mmol/L), median [Q1, Q3]

138.60 (136.00,141.00)

138.00 (134.82,141.43)

0.001

 Potassium (mmol/L), median [Q1, Q3]

4.15 (3.83,4.55)

4.28 (3.88,4.78)

 < 0.001

 Glucose (mmol/L), median [Q1, Q3]

128.50 (108.33,156.24)

131.00 (107.00,163.54)

0.130

 CRE (mg/dL), median [Q1, Q3]

1.05 (0.75,1.68)

1.35 (0.85,2.30)

 < 0.001

 BUN (mg/dL), median [Q1, Q3]

22.29 (15.00,37.67)

32.58 (20.67,52.35)

 < 0.001

Therapy (1st 24 h), n (%)

 Vasopressor

1799 (31.22)

538 (43.67)

 < 0.001

Scoring system

 GCS

13.00 (9.00,14.00)

8.00 (3.00,12.00)

 < 0.001

 SOFA

6.00 (4.00,9.00)

9.00 (6.00,12.00)

 < 0.001

 APSIII

55.00 (41.00,72.00)

80.50 (63.00,102.00)

 < 0.001

 SIRS

3.00 (2.00,3.00)

3.00 (2.75,4.00)

 < 0.001

  1. AIDS Acquired Immunodeficiency Syndrome, CCI Charlson Comorbidity Index, MAP Mean Artery Pressure, RBC Red Blood Cell, WBC White Blood Cell, MCH Mean Corpuscular Hemoglobin, MCHC Mean Corpuscular Hemoglobin Concentration, MCV Mean Corpuscular Volume, PLT Platelet, RDW Red blood cell volume Distribution Width, HCT Hematocrit, APTT Activated Partial Thromboplastin Time, PT Prothrombin Time, INR International Normalized Ratio, pH potential of Hydrogen, BE Buffer Excess, CRE Creatinine, BUN Blood Urea Nitrogen, GCS Glasgow Coma Score, SOFA Sepsis related Organ Failure Assessment, APSIII Acute Physiology Score III, SIRS Systemic Inflammatory Response Syndrome
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BMC Medical Research Methodology

ISSN: 1471-2288

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