Table 1 Comparison of sensitivity and specificity from tailored meta-analysis, conventional meta-analysis and results using THIN data
Sensitivity (95% CI) | Specificity (95% CI) | Euclidean distance (compared to THIN estimate) | In applicable region yes/no | |
|---|---|---|---|---|
Primary Care (THIN) | 0.93 (0.89 to 0.96) | 0.61 (0.60 to 0.63) | 0 | Yes |
Conventional MA (14 studies) | 0.94 (0.90 to 0.97) | 0.67 (0.57 to 0.76) | 0.059 | No |
Tailored MA (binomial) (3 studies) | 0.87 (0.77 to 0.94) | 0.65 (0.60 to 0.69) | 0.062 | Yes |
Tailored MA (Mahalanobis) (9 studies) | 0.98 (0.83 to 0.999) | 0.68 (0.64 to 0.72) | 0.088 | No |