Table 3 Example for binary endpoints. Responses rates for binary endpoints according to the arm and the period in the presence of step-wise trends for scenarios presented in “Design” section with λ0=λ2=0.25. Here X represents the observed response rate of arm 1 in period 2, which we vary in Fig. 5. Arm 1 is assumed to have a negative effect in period 1, corresponding to OR1<1 (OR1=0.4)
From: On model-based time trend adjustments in platform trials with non-concurrent controls
Period 1 | Period 2 | |||||
|---|---|---|---|---|---|---|
Control | Arm 1 | Arm 2 | Control | Arm 1 | Arm 2 | |
H0 | 0.7 | 0.48 | – | 0.75 | X | 0.75 |
H1 | 0.7 | 0.48 | – | 0.75 | X | 0.84 |