| Total (%) | RCTs (%) | NRSs (%) | RCTs/NRSs (%) |
---|---|---|---|---|
The rating of the certainty per outcome, n | 811 | 544 | 256 | 11 (5 studies) |
 High, n (%) | 84 (10.4) | 83 (15.3) | 1 (0.4) | 0 |
 Moderate, n (%) | 199 (24.5) | 151 (27.7) | 45 (17.6) | 3 (27.3) |
 Low, n (%) | 260 (32.1) | 185 (34.0) | 69 (27.0) | 6 (54.5) |
 Very low, n (%) | 268 (33.0) | 125 (23.0) | 141 (55.0) | 2 (18.2) |
Total number of downgrading domains, n | 1012 | 667 | 339 | 6 |
 Risk of bias, n (%) | 528 (52.2) | 358 (53.8) | 167 (49.3) | 3 (50.0) |
 Imprecision, n (%) | 278 (27.5) | 207 (31.0) | 71 (21.0) | 0 |
 Inconsistency, n (%) | 146 (14.4) | 84 (12.6) | 60 (17.7) | 2 (33.3) |
 Indirectness, n (%) | 55 (5.4) | 17 (2.5) | 37 (10.8) | 1 (16.7) |
 Publication bias, n (%) | 5 (0.5) | 1 (0.1) | 4 (1.2) | 0 |
Upgradings, n | 21 | 0 | 19 | 2 |
 Large effect, n (%) | 3 (14.3) | 0 | 1 (5.3) | 2 (100.0) |
 Dose–response, n (%) | 10 (47.6) | 0 | 10 (52.6) | 0 |
 Plausible confounding, n (%) | 8 (38.1) | 0 | 8 (42.1) | 0 |
Frequency of the rating domains | ||||
 Mean frequency, n of Downgradings domains, n / The rating of the certainty per outcome, n | 1.25 1012/811 | 1.23 667/544 | 1.32 339/256 | 0.55 6/11 |
  Risk of bias, n (% of outcomes downgraded) | 528 (65.1) | 358 (65.8) | 167 (65.2) | 3 (27.3) |
  Imprecision, n (% of outcomes downgraded) | 278 (34.3) | 207 (38.0) | 71 (27.7) | 0 |
  Inconsistency, n (% of outcomes downgraded) | 146 (18.0) | 84 (15.4) | 60 (23.4) | 2 (18.2) |
  Indirectness, n (% of outcomes downgraded) | 55 (6.8) | 17 (3.1) | 37 (14.5) | 1 (9.1) |
  Publication bias, n (% of outcomes downgraded) | 5 (0.6) | 1 (0.2) | 4 (1.6) | 0 |
 Mean frequency, n of Upgrading domains, n / The rating of the certainty per outcome, n | 0.03 21/811 | 0.00 0/544 | 0.07 19/256 | 0.18 2/11 |
  Large effect, n (% of outcomes upgraded) | 3 (0.4) | 0 | 1 (0.4) | 2 (18.2) |
  Dose–response, n (% of outcomes upgraded) | 10 (1.2) | 0 | 10 (3.9) | 0 |
  Plausible confounding, n (% of outcomes upgraded) | 8 (1.0) | 0 | 8 (3.1) | 0 |