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Fig. 3 | BMC Medical Research Methodology

Fig. 3

From: An innovative approach based on real-world big data mining for calculating the sample size of the reference interval established using transformed parametric and non-parametric methods

Fig. 3

Relationship between reference intervals of thyroid hormones and sample size. Briefly, the orange and cyan scatter points represent results of one in 1000 random samples, under different sample sizes. That is, the upper limit and lower limit of the RIs of the thyroid-related hormones under various sample sizes. The area enclosed by the grey band and black dotted lines is the 90% CI of the upper and lower limits of the RIs for thyroid-related hormones in different sample sizes. The black dotted line, in the center of the confidence band, represents the mean of the upper or lower limits of the RIs for 1000 samples under the same sample size. The methods for establishing RIs include transformed parametric and non-parametric methods in the figure on the left and the figure on the right, respectively

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