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Fig. 9 | BMC Medical Research Methodology

Fig. 9

From: Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study

Fig. 9

Estimation biases and coverage probabilities of the two approaches (GLMM at aggregated level (glmm_agg), marginal model with GEE at aggregated level (gee_agg)) using the USDo2 under the settings of \(M=48\), \(n=50\), linear effect \(\delta _j=-0.1(j-3)\), and \(\sigma _c^2 \in \{0.2, 0.5, 0.8\}\) with an AR1 correlation structure (\(r=0.8\)). (vc: variance component, trt*period1-5: treatment-by-period interaction at period 1-5)

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BMC Medical Research Methodology

ISSN: 1471-2288

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