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Table 5 A comparison of current practice with a review conducted in 2014

From: A systematic review of randomisation method use in RCTs and association of trial design characteristics with method selection

 

Study Characteristic

2014

(n = 167)a

2014 with HTA

(n = 196)a

2019

(n = 385)a

Cluster Randomised

No

160 (96)

184 (93)

348 (90)

Yes

7 (4)

12 (7)

37 (10)

Covariates included in the allocation

No

15 (10)

21 (11)

73 (19)

Yes

139 (90)

162 (89)

312 (81)

Number of covariates

1

53 (38)

63 (38)

121 (31)

2

54 (39)

57 (34)

86 (23)

3

23 (17)

25 (15)

61 (16)

4

6 (4)

8 (5)

24 (6)

5 + 

3 (2)

14 (8)

93 (24)

Number of Centres

Single Centre

9 (5)

18 (9)

67 (17)

Multicentre

158 (95)

178 (91)

318 (83)

Number of Arms

2

129 (77)

149 (76)

319 (83)

3

16 (10)

23 (12)

45 (12)

4

14 (8)

16 (9)

15 (4)

5 + 

8 (5)

8 (4)

6 (1)

Allocation Method

Purely Random

1 (1)

2 (1)

25 (6)

Blocked

15 (10)

20 (11)

35 (9)

Stratified or Stratified Block

123 (79)

135 (74)

244 (64)

Minimisation/Covariate adaptive

14 (9)

23 (13)

57 (15)

Other

2 (1)

3 (1)

24 (6)

  1. Unless otherwise specified, the table reports the number of studies along with column percentages
  2. a Percentages are based on non-missing values