Fig. 4From: Evaluation of two-stage designs of Phase 2 single-arm trials in glioblastoma: a systematic reviewExample of Adaptive Design to handle the uncertainty for Phase 2 two-stage design. A Phase 2 single-arm study using two-stage design [42], where a new treatment option of hypoxia activated evofosfamide (TH302) for patient with recurrent bevacizumab-refractory glioblastoma was investigatedBack to article page